SCYNEXIS to Present Preclinical Data on Second Generation IV/Oral Fungerp SCY-247 at the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)

GlobeNewswire Inc.

April 08, 2025 12:01PM GMT

JERSEY CITY, N.J., April 08, 2025 (GLOBE NEWSWIRE) -- SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology company pioneering innovative medicines to overcome and prevent difficult-to-treat and drug-resistant infections, today announced the presentation of preclinical efficacy data on its second-generation fungerp candidate SCY-247 at the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Global) in Vienna, Austria being held from April 11-15, 2025.

SCY-247 is being developed to address systemic fungal diseases, with a key focus on invasive fungal infections where resistance to current limited treatment options is a significant concern. These presentations at ESCMID Global 2025 continue to build upon SCY-247’s positive preclinical data illustrating its unique attributes in the fight against difficult-to-treat fungal infections, including its potent antifungal activity against multi drug-resistant fungi.

Poster Presentations:

Title:

Antifungal susceptibility testing of SCY-247 against contemporary clinical yeast isolates

Poster Number:

P2909

Session Title:

06d. Antifungal susceptibility testing & resistance (incl surveillance, mechanisms)

Session Date/Time:

Saturday, April 12 at 12:00 pm CET

Presenting author:

Luis Ostrosky-Zeichner MD, UTHealth Houston, USA

Details:Candida

spp are the most prevalent fungal pathogen causing infection in hospitalized patients in the US. This

in vitro

study performed at the University of Texas, Houston, compared SCY-247 and 7 other antifungal agents against 171 clinical yeast isolates.

SCY-247 demonstrated antifungal activity against clinically relevant yeasts, including epidemiologically-relevant species such as

Candida auris

and fluconazole-resistant

Candida parapsilosis

.

 

Title:

The new triterpenoid antifungal SCY-247 retained activity against most echinocandin- and fluconazole-resistant 

Candida

 spp isolates: reduced susceptibility in 

C. glabrata

 isolates showing substitutions at the first amino acid in hotspot 1 FKS2 gene

Poster Number:

P2924

Session Title:

06d. Antifungal susceptibility testing & resistance (incl surveillance, mechanisms)

Session Date/Time:

Saturday, April 12 at 12:00 pm CET

Presenting author:

Jesus Guinea, PharmD, PhD, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Details:

Resistance against currently available antifungal treatments among

Candida

species is growing in the clinical setting. The aim of this study was to assess the

in vitro

antifungal activity profile of SCY-247 against a collection of 161 Spanish antifungal-resistant

Candida

spp isolates harboring various resistance mechanisms (97 fluconazole-resistant, 41 fluconazole-susceptible and echinocandin resistant and 23 fluconazole and echinocandin resistant isolates). SCY-247 retained

in vitro

activity against the majority of antifungal-resistant

Candida

spp. isolates, including echinocandin-resistant isolates. However, SCY-247 showed MIC’s above the wild-type distribution against

C. glabrata

isolates harbouring select mutations at position F659 of the FKS2 gene).

 

Title:

SCY-247, a novel second-generation IV/oral triterpenoid antifungal, demonstrates 

in vitro

 activity against 

C. auris

 including the majority of strains exhibiting high MICs for echinocandins

Poster Number:

P2955

Session Title:

06e. Antifungal drugs & treatment (incl pre-clinical studies and clinical trials)

Session Date/Time:

Saturday, April 12 at 12:00 pm CET

Presenting author:

Eelco F.J. Meijer MD PhD, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

Details:Candida auris

is a highly resistant fungal pathogen that has caused large and persistent outbreaks in the healthcare setting. The aim of the study was to test the

in vitro

activity of SCY-247 against 65

Candida auris

isolates representing 5 different clades around the world, including 51 wild-type (WT) 14 echinocandin-resistant (FKS1 mutations)

C. auris

isolates. SCY-247 demonstrates robust

in vitro

activity against WT and ECH-R isolates. Notably, SCY-247 MICs are lower than echinocandins for all

FKS1

mutants, especially against most common mutations at position S639 (FKS 1 gene).

 

Title:

Assessment of 

in vitro

 activity of the new triterpenoid antifungal, SCY-247, against a collection of yeasts causing fungaemia in patients admitted to a tertiary hospital in Madrid from 2014 to 2024

Poster Number:

P2966

Session:

06e. Antifungal drugs & treatment (incl pre-clinical studies and clinical trials)

Session Date/Time:

Saturday, April 12 at 12:00 pm CET

Presenting author:

Jesus Guinea, PharmD, PhD, Hospital General Universitario Gregorio Marañon, Madrid, Spain

Details:

Fungemias caused by

Candida

spp. are the most common type of fungal blood stream infection. This study explored the

in vitro

antifungal activity profile of SCY-247 against 537 fungemia yeast isolates (antifungal resistant and susceptible) from patients admitted to a large hospital in Madrid, Spain. SCY-247 demonstrated potent

in vitro

activity against a collection of clinical

Candida

spp isolates causing fungaemia.

 

For more information, see the ESCMID website here.

About SCY-247

SCY-247 is a second-generation antifungal compound, from a novel class of structurally-distinct glucan synthase inhibitors, triterpenoids (fungerps), being developed to address the significant threat posed by antimicrobial resistance (AMR) in systemic fungal diseases with high mortality. The triterpenoid class of antifungals represents the first new class of antifungal compounds approved since 2001. These agents combine the well-established activity of glucan synthase inhibitors with the potential flexibility of having oral and intravenous (IV) formulations. SCY-247 is in Phase 1 of development and has demonstrated in vitro and in vivo broad-spectrum antifungal activity, including against multidrug resistant fungal pathogens. SCYNEXIS anticipates that the U.S. Food and Drug Administration (FDA) may grant SCY-247 Qualified Infectious Disease Product (QIDP) and Fast Track designations for both the IV and oral formulations of SCY-247.

About SCYNEXIS

SCYNEXIS, Inc. (NASDAQ: SCYX) is a biotechnology company pioneering innovative medicines to help millions of patients worldwide overcome and prevent difficult-to-treat infections that are becoming increasingly drug-resistant. SCYNEXIS is developing the company’s proprietary antifungal platform “fungerps.” Ibrexafungerp, the first representative of this novel class, has been licensed to GSK. The U.S. Food and Drug Administration (FDA) approved BREXAFEMME® (ibrexafungerp tablets) in June 2021, for its first indication in vulvovaginal candidiasis (VVC), followed by a second indication in November 2022, for reduction in the incidence of recurrent VVC. Late-stage clinical investigation of ibrexafungerp for the treatment of life-threatening invasive fungal infections in hospitalized patients is ongoing. Additional antifungal assets from this novel class are currently in clinical, pre- clinical and discovery phases, including the compound SCY-247. For more information, visit www.scynexis.com.

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