If you invested $1000 in Upstream Bio, Inc. (UPB) since IPO date, it would be worth $124.55 as of October 25, 2026, based on a reinvested dividends scenario. Over the same period, a $1000 investment made 1 year ago would be worth $116.2, while $1000 invested 6 months ago would be worth $294.94. This corresponds to total returns of -87.55%, -88.38%, -70.51%, respectively, with annualized returns of -64.01%, -88.38%, -70.51%.
Custom investment amounts or purchase dates can also be explored using the Stoculator calculator. Past performance does not guarantee future results.
Date Range:
| Date | Open | Close | Adj Close | High | Low | Volume |
|---|---|---|---|---|---|---|
| October 23, 2026 | 2.95 | 2.74 | 2.74 | 2.96 | 2.7 | 1.05M |
| October 22, 2026 | 2.77 | 2.99 | 2.99 | 2.99 | 2.7 | 1.45M |
| October 21, 2026 | 2.83 | 2.8 | 2.8 | 2.98 | 2.77 | 1.41M |
| October 20, 2026 | 2.79 | 2.82 | 2.82 | 3.09 | 2.78 | 1.67M |
| October 19, 2026 | 2.76 | 2.8 | 2.8 | 3.07 | 2.75 | 1.6M |
| October 16, 2026 | 3.39 | 2.76 | 2.76 | 3.39 | 2.74 | 1.84M |
| October 15, 2026 | 3.44 | 3.37 | 3.37 | 3.56 | 3.29 | 1.29M |
| October 14, 2026 | 3.48 | 3.42 | 3.42 | 3.6 | 3.29 | 1.58M |
| October 13, 2026 | 4.14 | 3.55 | 3.55 | 4.16 | 3.52 | 1.04M |
| October 12, 2026 | 4.68 | 4.17 | 4.17 | 4.72 | 4.12 | 848,407 |
| October 09, 2026 | 4.54 | 4.7 | 4.7 | 4.76 | 4.51 | 1.19M |
| October 08, 2026 | 4.53 | 4.55 | 4.55 | 4.65 | 4.37 | 2.86M |
| October 07, 2026 | 4.55 | 4.61 | 4.61 | 4.72 | 4.5 | 908,400 |
| October 06, 2026 | 4.84 | 4.59 | 4.59 | 4.87 | 4.53 | 1.06M |
| October 05, 2026 | 5.07 | 4.85 | 4.85 | 5.1 | 4.67 | 1.01M |
| October 02, 2026 | 5.12 | 5.04 | 5.04 | 5.21 | 4.86 | 956,519 |
| October 01, 2026 | 5.25 | 5.04 | 5.04 | 5.35 | 4.98 | 832,377 |
| September 30, 2026 | 5.23 | 5.27 | 5.27 | 5.46 | 5.15 | 851,221 |
| September 29, 2026 | 5.28 | 5.19 | 5.19 | 5.31 | 4.99 | 784,211 |
| September 28, 2026 | 5.34 | 5.3 | 5.3 | 5.39 | 5.12 | 615,400 |
| September 25, 2026 | 5.2 | 5.36 | 5.36 | 5.39 | 5.07 | 429,109 |
| September 24, 2026 | 5.19 | 5.17 | 5.17 | 5.2 | 5.05 | 566,581 |
| September 23, 2026 | 5.48 | 5.19 | 5.19 | 5.49 | 4.99 | 552,993 |
| September 22, 2026 | 5.44 | 5.49 | 5.49 | 5.56 | 5.38 | 360,398 |
| September 21, 2026 | 5.34 | 5.37 | 5.37 | 5.41 | 5.28 | 364,034 |
| September 18, 2026 | 5.32 | 5.34 | 5.34 | 5.41 | 5.21 | 1M |
| September 17, 2026 | 5.44 | 5.31 | 5.31 | 5.48 | 5.24 | 533,870 |
| September 16, 2026 | 5.49 | 5.33 | 5.33 | 5.54 | 5.27 | 497,239 |
| September 15, 2026 | 5.81 | 5.48 | 5.48 | 5.81 | 5.46 | 421,257 |
| September 11, 2026 | 5.84 | 5.73 | 5.73 | 5.84 | 5.65 | 501,306 |
| September 10, 2026 | 5.86 | 5.75 | 5.75 | 5.86 | 5.67 | 562,400 |
| September 09, 2026 | 6.14 | 5.96 | 5.96 | 6.2 | 5.77 | 726,235 |
| September 08, 2026 | 6.01 | 6.19 | 6.19 | 6.21 | 5.77 | 949,238 |
| September 04, 2026 | 6 | 6.01 | 6.01 | 6.23 | 5.97 | 642,840 |
| September 03, 2026 | 6.49 | 6.08 | 6.08 | 6.49 | 5.77 | 1.35M |
| September 02, 2026 | 6.62 | 6.48 | 6.48 | 6.98 | 6.41 | 515,403 |
| September 01, 2026 | 6.58 | 6.55 | 6.55 | 6.72 | 6.5 | 476,485 |
| August 31, 2026 | 6.64 | 6.62 | 6.62 | 6.77 | 6.44 | 895,007 |
| August 28, 2026 | 6.71 | 6.69 | 6.69 | 6.79 | 6.6 | 445,475 |
| August 27, 2026 | 7.11 | 6.79 | 6.79 | 7.14 | 6.78 | 335,060 |
| August 26, 2026 | 7.18 | 7.13 | 7.13 | 7.31 | 6.9 | 432,930 |
| August 25, 2026 | 6.68 | 7.18 | 7.18 | 7.18 | 6.55 | 554,212 |
| August 24, 2026 | 7 | 6.61 | 6.61 | 7.11 | 6.46 | 538,535 |
| August 21, 2026 | 6.91 | 6.97 | 6.97 | 7.01 | 6.85 | 434,240 |
| August 20, 2026 | 7.48 | 6.85 | 6.85 | 7.56 | 6.75 | 592,928 |
| August 19, 2026 | 7.04 | 7.52 | 7.52 | 7.52 | 6.93 | 0 |
| August 18, 2026 | 7.28 | 6.85 | 6.85 | 7.44 | 6.73 | 461,648 |
| August 17, 2026 | 7.02 | 7.14 | 7.14 | 7.19 | 6.86 | 852,439 |
| August 14, 2026 | 6.95 | 7.07 | 7.07 | 7.14 | 6.8 | 688,248 |
| August 13, 2026 | 7.02 | 6.91 | 6.91 | 7.04 | 6.87 | 378,828 |
| August 12, 2026 | 7 | 6.91 | 6.91 | 7.25 | 6.84 | 0 |
| August 11, 2026 | 7.48 | 7.09 | 7.09 | 7.7 | 7.01 | 0 |
| August 10, 2026 | 7.32 | 7.44 | 7.44 | 7.62 | 7.2 | 869,590 |
| August 07, 2026 | 6.94 | 7.25 | 7.25 | 7.26 | 6.89 | 621,836 |
| August 06, 2026 | 6.75 | 6.87 | 6.87 | 7.17 | 6.66 | 427,171 |
| August 05, 2026 | 6.77 | 6.74 | 6.74 | 6.88 | 6.58 | 917,141 |
| August 04, 2026 | 6.4 | 6.79 | 6.79 | 6.92 | 6.4 | 1.36M |
| August 03, 2026 | 6.24 | 6.42 | 6.42 | 6.43 | 6.18 | 748,448 |
| July 31, 2026 | 6.58 | 6.31 | 6.31 | 6.69 | 6.29 | 297,713 |
| July 30, 2026 | 6.35 | 6.57 | 6.57 | 6.67 | 6.29 | 320,622 |